Research Interests

Our lab is interested in understanding the molecular mechanisms that regulate the complex structure and function of the endoplasmic reticulum (ER). The ER is the largest membrane-bound organelle in the cell, extending from the nuclear envelope throughout the cytoplasm as an elaborate network of cisternae and tubules. Elucidating the functional relevance of these domains as well as the molecular basis for generating and maintaining them is a major goal. In addition to its complex structure, the ER is highly dynamic and we have become increasingly interested in identifying the machineries that facilitate these dynamics. From a broader point of view, it is particularly intriguing to think about the cellular importance of ER structure and dynamics. Recently we have begun to address this through the identification of new roles for the ER at inter-organelle contact sites, which have portrayed the ER as a “master regulator” within the cell. Through these studies we aim to elucidate the complex interplay between ER biogenesis and its function at the cellular level.